Nonsense-mediated mRNA decay

Jikai Wen; Saverio Brogna

doi:10.1042/BST0360514

Nonsense-mediated mRNA decay

Jikai Wen
, Saverio Brogna

Biosciences

Research output: Contribution to journal › Review article

36 Citations (Scopus)

Abstract

Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.

Original language	English
Pages (from-to)	514-516
Number of pages	3
Journal	Biochemical Society Transactions
Volume	36
DOIs	https://doi.org/10.1042/BST0360514
Publication status	Published - 1 Jun 2008

Keywords

splicing
exon-exon junction complex (EJC)
translation
intron
nuclear translation
nonsense-mediated mRNA decay (NMD)

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10.1042/BST0360514

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title = "Nonsense-mediated mRNA decay",

abstract = "Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.",

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AU - Wen, Jikai

AU - Brogna, Saverio

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N2 - Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.

AB - Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.

KW - splicing

KW - exon-exon junction complex (EJC)

KW - translation

KW - intron

KW - nuclear translation

KW - nonsense-mediated mRNA decay (NMD)

U2 - 10.1042/BST0360514

DO - 10.1042/BST0360514

M3 - Review article

C2 - 18481993

SN - 0300-5127

VL - 36

SP - 514

EP - 516

JO - Biochemical Society Transactions

JF - Biochemical Society Transactions

ER -

Nonsense-mediated mRNA decay

Abstract

Keywords

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