Abstract
Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.
Original language | English |
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Pages (from-to) | 514-516 |
Number of pages | 3 |
Journal | Biochemical Society Transactions |
Volume | 36 |
DOIs | |
Publication status | Published - 1 Jun 2008 |
Keywords
- splicing
- exon-exon junction complex (EJC)
- translation
- intron
- nuclear translation
- nonsense-mediated mRNA decay (NMD)