Nonsense-mediated mRNA decay

Jikai Wen, Saverio Brogna

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation termination? Surprisingly, in mammalian cells, PTC recognition is linked to pre-mRNA splicing. Here, we review the Current understanding in view of recent developments.
Original languageEnglish
Pages (from-to)514-516
Number of pages3
JournalBiochemical Society Transactions
Volume36
DOIs
Publication statusPublished - 1 Jun 2008

Keywords

  • splicing
  • exon-exon junction complex (EJC)
  • translation
  • intron
  • nuclear translation
  • nonsense-mediated mRNA decay (NMD)

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