Non-steroidal anti-inflammatory drugs and renal failure

D H Adams, A J Howie, J Michael, B McConkey, P A Bacon, D Adu

Research output: Contribution to journalArticlepeer-review

100 Citations (Scopus)


In 3 years seventeen patients presented to one unit with renal failure associated with the use of non-steroidal anti-inflammatory drugs (NSAID). Seven patients presented with acute renal failure, in four due to acute tubular necrosis and in three to acute interstitial nephritis; all recovered when NSAID treatment was stopped. Four patients presented with symptomless renal impairment discovered during routine follow-up in a rheumatology clinic; again all improved on withdrawal of NSAID. The remaining six patients presented with chronic renal failure, a disorder not previously associated with NSAID treatment. The pattern of renal disease associated with NSAID may be more extensive than has previously been recognised. A history of NSAID use should be sought in all patients presenting with unexplained renal failure.
Original languageEnglish
Pages (from-to)57-60
Number of pages4
Issue number8472
Publication statusPublished - 11 Jan 1986


  • Acute Kidney Injury
  • Adult
  • Aged
  • Anti-Inflammatory Agents
  • Apazone
  • Creatinine
  • Female
  • Humans
  • Kidney Failure, Chronic
  • Kidney Tubular Necrosis, Acute
  • Male
  • Middle Aged
  • Naproxen
  • Nephritis, Interstitial
  • Piroxicam
  • Proteinuria
  • Thiazines


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