Non-invasive Instrument-based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review

Xiaoxuan Liu; Thomas W McNally; Sophie Beese; Laura E Downie; Ameenat L Solebo; Livia  Faes; Syed Husain; Pearse A Keane; David Moore; Alastair Denniston

Non-invasive Instrument-based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review

Xiaoxuan Liu
, Thomas W McNally
, Sophie Beese
, Laura E Downie
, Ameenat L Solebo
, Livia Faes
, Syed Husain
, Pearse A Keane
, David Moore
, Alastair Denniston

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures of AC flare.
Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability.
Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM.
Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.

Original language	English
Journal	Ocular immunology and inflammation
Publication status	Accepted/In press - 23 Dec 2019

Keywords

Systematic review
uveitis
anterior chamber flare
aqueous humor
aqueous humour
Tyndall effect
diagnostic test
aqueous protein concentration
optical coherence tomography
laser flare photometry

Cite this

@article{190c09fcae2a468c8c38cedfa696b108,

title = "Non-invasive Instrument-based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review",

abstract = "Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures of AC flare. Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability. Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM. Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests. ",

keywords = "Systematic review, uveitis, anterior chamber flare, aqueous humor, aqueous humour, Tyndall effect, diagnostic test, aqueous protein concentration, optical coherence tomography, laser flare photometry",

author = "Xiaoxuan Liu and McNally, \{Thomas W\} and Sophie Beese and Downie, \{Laura E\} and Solebo, \{Ameenat L\} and Livia Faes and Syed Husain and Keane, \{Pearse A\} and David Moore and Alastair Denniston",

year = "2019",

month = dec,

day = "23",

language = "English",

journal = "Ocular immunology and inflammation",

issn = "0927-3948",

publisher = "Taylor \& Francis",

}

TY - JOUR

T1 - Non-invasive Instrument-based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review

AU - Liu, Xiaoxuan

AU - McNally, Thomas W

AU - Beese, Sophie

AU - Downie, Laura E

AU - Solebo, Ameenat L

AU - Faes, Livia

AU - Husain, Syed

AU - Keane, Pearse A

AU - Moore, David

AU - Denniston, Alastair

PY - 2019/12/23

Y1 - 2019/12/23

N2 - Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures of AC flare. Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability. Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM. Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.

AB - Purpose: Anterior chamber (AC) flare is a key sign for anterior uveitis. New instrument-based techniques for measuring AC flare can offer automation and objectivity. This review aims to identify objective instrument-based measures of AC flare. Methods: In this systematic review, we identified studies reporting correlation between instrument-based tests versus clinician AC flare grading, and/or aqueous protein concentration, as well as test reliability. Results: Four index tests were identified in 11 studies: laser-flare photometry (LFP), optical coherence tomography, ocular flare analysis meter (OFAM) and the double-pass technique. The correlation between LFP and clinician grading and protein concentration was 0.40-0.93 and 0.87-0.94, respectively. The double-pass technique showed no correlation with clinician grading and insufficient information was available for OFAM. Conclusion: LFP shows moderate to strong correlation with clinician grading and aqueous protein concentration. LFP could be a superior reference test compared to clinician AC flare grading for validating new index tests.

KW - Systematic review

KW - uveitis

KW - anterior chamber flare

KW - aqueous humor

KW - aqueous humour

KW - Tyndall effect

KW - diagnostic test

KW - aqueous protein concentration

KW - optical coherence tomography

KW - laser flare photometry

M3 - Article

SN - 0927-3948

JO - Ocular immunology and inflammation

JF - Ocular immunology and inflammation

ER -

Non-invasive Instrument-based Tests for Quantifying Anterior Chamber Flare in Uveitis: A Systematic Review

Abstract

Keywords

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