@inbook{65414e4fcfbd4ab1b3820455a21b818f,
title = "Non-covalent metallo-drugs: using shape to target DNA and RNA junctions and other nucleic acid structures",
abstract = "The most effective class of anticancer drugs in clinical use are the platins which act by binding to duplex B-DNA. Yet duplex DNA is not DNA in its active form, and many other structures are formed in cells; for example, Y-shaped fork structures are involved in DNA replication and transcription and 4-way junctions with DNA repair. In this chapter we explore how large, cationic metallo-supramolecular structures can be used to bind to these less common, yet active, nucleic acid structures.",
keywords = "Animals, Antineoplastic Agents/chemistry, Binding Sites, Coordination Complexes, DNA, Neoplasm/chemistry, Drug Design, G-Quadruplexes, Humans, Models, Molecular, Neoplasms/drug therapy, Nucleic Acid Conformation, Organometallic Compounds/chemistry, RNA, Neoplasm/chemistry, Structure-Activity Relationship",
author = "Lucia Cardo and Hannon, {Michael J}",
year = "2018",
month = feb,
day = "5",
doi = "10.1515/9783110470734-017",
language = "English",
series = "Metal Ions in Life Sciences",
publisher = "Walter de Gruyter GmbH & Co. KG",
pages = "303--324",
booktitle = "Metallo-drugs",
address = "Germany",
}