TY - JOUR
T1 - NF-κB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS
AU - Harris, TH
AU - Wilson, EH
AU - Tait, ED
AU - Shapira, S
AU - Caamano, Jorge
AU - Artis, D
AU - Hunter, CA
AU - Buckley, Marie
PY - 2010/5/1
Y1 - 2010/5/1
N2 - In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer studies revealed that NF-kappaB1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii.
AB - In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer studies revealed that NF-kappaB1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii.
U2 - 10.1016/j.jneuroim.2009.12.009
DO - 10.1016/j.jneuroim.2009.12.009
M3 - Article
C2 - 20156658
SN - 1872-8421
VL - 222
SP - 19
EP - 28
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -