New pharmacological strategies for the treatment of heart failure

Bernard Chin, Gregory Lip

Research output: Contribution to journalReview article

7 Citations (Scopus)


Heart failure still carries a high morbidity and mortality, necessitating new approaches for its management. Greater understanding of the pathophysiology of heart failure has opened the way for novel therapeutic approaches, including analogs of natriuretic peptides and drugs that modulate endothelin, cytokine release and endothelial vasoconstriction. Other drugs are undergoing laboratory and clinical trials that will eventually supersede or complement less optimal heart failure treatments. Clinical trials will ascertain if these new strategies in the treatment of heart failure will ultimately be successful in the management of these patients.
Original languageEnglish
Pages (from-to)923-928
Number of pages6
JournalCurrent Opinion in Investigational Drugs
Publication statusPublished - 1 Jan 2001


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