New horizons for Idiopathic intracranial hypertension: advances and challenges

Susan Mollan; Olivia Grech; Zerin Alimajstorovic; Benjamin Wakerley; Alex Sinclair

doi:10.1093/bmb/ldaa034

New horizons for Idiopathic intracranial hypertension: advances and challenges

Susan Mollan
, Olivia Grech
, Zerin Alimajstorovic
, Benjamin Wakerley
, Alex Sinclair

Research output: Contribution to journal › Article › peer-review

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Abstract

Introduction
Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic.

Sources of data
All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered.

Areas of agreement
Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management.

Areas of controversy
Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached.

Growing points
Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based.

Areas timely for developing research
Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.

Original language	English
Article number	ldaa034
Pages (from-to)	118-126
Number of pages	9
Journal	British Medical Bulletin
Volume	136
Issue number	1
Early online date	16 Nov 2020
DOIs	https://doi.org/10.1093/bmb/ldaa034
Publication status	Published - 15 Dec 2020

Bibliographical note

Publisher Copyright:
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: [email protected].

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

GLP-1
androgens
headache
idiopathic intracranial hypertension
obesity
papilloedema
pseudotumour cerebri
raised intracranial pressure

ASJC Scopus subject areas

General Medicine

Access to Document

10.1093/bmb/ldaa034Licence: None: All rights reserved

MollanS2020NewAccepted author manuscript, 162 KBLicence: None: All rights reserved

Cite this

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title = "New horizons for Idiopathic intracranial hypertension: advances and challenges",

abstract = "Introduction Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic. Sources of data All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered. Areas of agreement Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management. Areas of controversy Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached. Growing points Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based. Areas timely for developing research Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.",

keywords = "GLP-1, androgens, headache, idiopathic intracranial hypertension, obesity, papilloedema, pseudotumour cerebri, raised intracranial pressure",

author = "Susan Mollan and Olivia Grech and Zerin Alimajstorovic and Benjamin Wakerley and Alex Sinclair",

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T2 - advances and challenges

AU - Mollan, Susan

AU - Grech, Olivia

AU - Alimajstorovic, Zerin

AU - Wakerley, Benjamin

AU - Sinclair, Alex

PY - 2020/12/15

Y1 - 2020/12/15

N2 - Introduction Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic. Sources of data All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered. Areas of agreement Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management. Areas of controversy Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached. Growing points Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based. Areas timely for developing research Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.

AB - Introduction Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic. Sources of data All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered. Areas of agreement Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management. Areas of controversy Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached. Growing points Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based. Areas timely for developing research Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.

KW - GLP-1

KW - androgens

KW - headache

KW - idiopathic intracranial hypertension

KW - obesity

KW - papilloedema

KW - pseudotumour cerebri

KW - raised intracranial pressure

UR - http://bmb.oxfordjournals.org/

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New horizons for Idiopathic intracranial hypertension: advances and challenges

Abstract

Bibliographical note

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this