New horizons for Idiopathic intracranial hypertension

Susan Mollan, Olivia Grech, Zerin Alimajstorovic, Benjamin Wakerley, Alex Sinclair

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Idiopathic intracranial hypertension (IIH) is becoming a recognized condition due to the increasing incidence linked to a global obesity epidemic.

Sources of data
All English papers on PubMed, Cochrane and Scholar between inception until 1 March 2020 were considered.

Areas of agreement
Studies suggest central adiposity has a pathogenic role. Recent weight gain is a risk factor and weight loss has a key role in management.

Areas of controversy
Interpretation of abnormal lumbar puncture opening pressure is debated. There is an increasing recognition of obesity stigma and how this should be approached.

Growing points
Further evidence is required for the choice of surgical intervention for fulminant IIH. Education regarding IIH should be evidence based.

Areas timely for developing research
Novel research of the pathology of IIH is influencing development of therapies such as glucagon-like peptide-1 receptor agonists and targeting unique androgen signatures. The newly discovered cardiovascular risk requires further attention.
Original languageEnglish
Article numberldaa034
JournalBritish Medical Bulletin
Early online date16 Nov 2020
Publication statusE-pub ahead of print - 16 Nov 2020

Bibliographical note

Not yet published in issue as of 02/12/2020.


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