New approaches to investigate drug-induced hypersensitivity

Monday O Ogese, Shaheda Ahmed, Ana Alfirevic, Catherine J Betts, Anne Dickinson, Lee Faulkner, Neil S French, Andrew Gibson, Gideon M Hirschfield, Michael Ernst Kammüller, Xiaoli Meng, Stefan F Martin, Philippe Musette, Alan Norris, Munir Pirmohamed, Brian Kevin Park, Anthony Wayne Purcell, Colin F Spraggs, Jessica Whritenour, Dean John Naisbitt

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


The workshop on "New approaches to investigate drug-induced hypersensitivity" was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts' views on the different topics covered during the meeting.

Original languageEnglish
Pages (from-to)239–259
JournalChemical Research in Toxicology
Issue number1
Early online date2 Nov 2016
Publication statusPublished - Jan 2017


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