New approaches to investigate drug-induced hypersensitivity

Monday O Ogese; Shaheda Ahmed; Ana Alfirevic; Catherine J Betts; Anne Dickinson; Lee Faulkner; Neil S French; Andrew Gibson; Gideon M Hirschfield; Michael Ernst Kammüller; Xiaoli Meng; Stefan F Martin; Philippe Musette; Alan Norris; Munir Pirmohamed; Brian Kevin Park; Anthony Wayne Purcell; Colin F Spraggs; Jessica Whritenour; Dean John Naisbitt

doi:10.1021/acs.chemrestox.6b00333

New approaches to investigate drug-induced hypersensitivity

Monday O Ogese, Shaheda Ahmed, Ana Alfirevic, Catherine J Betts, Anne Dickinson, Lee Faulkner, Neil S French, Andrew Gibson, Gideon M Hirschfield, Michael Ernst Kammüller, Xiaoli Meng, Stefan F Martin, Philippe Musette, Alan Norris, Munir Pirmohamed, Brian Kevin Park, Anthony Wayne Purcell, Colin F Spraggs, Jessica Whritenour, Dean John Naisbitt

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The workshop on "New approaches to investigate drug-induced hypersensitivity" was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts' views on the different topics covered during the meeting.

Original language	English
Pages (from-to)	239–259
Journal	Chemical Research in Toxicology
Volume	30
Issue number	1
Early online date	2 Nov 2016
DOIs	https://doi.org/10.1021/acs.chemrestox.6b00333
Publication status	Published - Jan 2017

Access to Document

10.1021/acs.chemrestox.6b00333

Cite this

Ogese, M. O., Ahmed, S., Alfirevic, A., Betts, C. J., Dickinson, A., Faulkner, L., French, N. S., Gibson, A., Hirschfield, G. M., Kammüller, M. E., Meng, X., Martin, S. F., Musette, P., Norris, A., Pirmohamed, M., Park, B. K., Purcell, A. W., Spraggs, C. F., Whritenour, J., & Naisbitt, D. J. (2017). New approaches to investigate drug-induced hypersensitivity. Chemical Research in Toxicology, 30(1), 239–259. Advance online publication. https://doi.org/10.1021/acs.chemrestox.6b00333

@article{d097c80a50eb4300b3323bb794816484,

title = "New approaches to investigate drug-induced hypersensitivity",

abstract = "The workshop on {"}New approaches to investigate drug-induced hypersensitivity{"} was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts' views on the different topics covered during the meeting.",

author = "Ogese, {Monday O} and Shaheda Ahmed and Ana Alfirevic and Betts, {Catherine J} and Anne Dickinson and Lee Faulkner and French, {Neil S} and Andrew Gibson and Hirschfield, {Gideon M} and Kamm{\"u}ller, {Michael Ernst} and Xiaoli Meng and Martin, {Stefan F} and Philippe Musette and Alan Norris and Munir Pirmohamed and Park, {Brian Kevin} and Purcell, {Anthony Wayne} and Spraggs, {Colin F} and Jessica Whritenour and Naisbitt, {Dean John}",

year = "2017",

month = jan,

doi = "10.1021/acs.chemrestox.6b00333",

language = "English",

volume = "30",

pages = "239–259",

journal = "Chemical Research in Toxicology",

issn = "0893-228X",

publisher = "American Chemical Society",

number = "1",

}

Ogese, MO, Ahmed, S, Alfirevic, A, Betts, CJ, Dickinson, A, Faulkner, L, French, NS, Gibson, A, Hirschfield, GM, Kammüller, ME, Meng, X, Martin, SF, Musette, P, Norris, A, Pirmohamed, M, Park, BK, Purcell, AW, Spraggs, CF, Whritenour, J & Naisbitt, DJ 2017, 'New approaches to investigate drug-induced hypersensitivity', Chemical Research in Toxicology, vol. 30, no. 1, pp. 239–259. https://doi.org/10.1021/acs.chemrestox.6b00333

TY - JOUR

T1 - New approaches to investigate drug-induced hypersensitivity

AU - Ogese, Monday O

AU - Ahmed, Shaheda

AU - Alfirevic, Ana

AU - Betts, Catherine J

AU - Dickinson, Anne

AU - Faulkner, Lee

AU - French, Neil S

AU - Gibson, Andrew

AU - Hirschfield, Gideon M

AU - Kammüller, Michael Ernst

AU - Meng, Xiaoli

AU - Martin, Stefan F

AU - Musette, Philippe

AU - Norris, Alan

AU - Pirmohamed, Munir

AU - Park, Brian Kevin

AU - Purcell, Anthony Wayne

AU - Spraggs, Colin F

AU - Whritenour, Jessica

AU - Naisbitt, Dean John

PY - 2017/1

Y1 - 2017/1

N2 - The workshop on "New approaches to investigate drug-induced hypersensitivity" was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts' views on the different topics covered during the meeting.

AB - The workshop on "New approaches to investigate drug-induced hypersensitivity" was held on June 5 2014 at the Foresight centre, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical and chemical basis of small molecule drug hypersensitivity (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, (3) identify the limitations, knowledge gaps and challenges that limit the use of these assays and utilise the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective article reviews the clinical and immunological bases of drug hypersensitivity and summarises various experts' views on the different topics covered during the meeting.

U2 - 10.1021/acs.chemrestox.6b00333

DO - 10.1021/acs.chemrestox.6b00333

M3 - Article

C2 - 27806199

SN - 0893-228X

VL - 30

SP - 239

EP - 259

JO - Chemical Research in Toxicology

JF - Chemical Research in Toxicology

IS - 1

ER -

New approaches to investigate drug-induced hypersensitivity

Abstract

Access to Document

Fingerprint

Cite this