Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation

Mengliang Wu, Lisa J. Hill, Laura E. Downie, Holly R. Chinnery

Research output: Contribution to journalReview articlepeer-review

41 Downloads (Pure)


In the cornea, resident immune cells are in close proximity to sensory nerves, consistent with their important roles in the maintenance of nerves in both homeostasis and inflammation. Using in vivo confocal microscopy in humans, and ex vivo immunostaining and fluorescent reporter mice to visualize corneal sensory nerves and immune cells, remarkable progress has been made to advance our understanding of the physical and functional interactions between corneal nerves and immune cells. In this review, we summarize and discuss recent studies relating to corneal immune cells and sensory nerves, and their interactions in health and disease. In particular, we consider how disrupted corneal nerve axons can induce immune cell activity, including in dendritic cells, macrophages and other infiltrating cells, directly and/or indirectly by releasing neuropeptides such as substance P and calcitonin gene-related peptide. We summarize growing evidence that the role of corneal intraepithelial immune cells is likely different in corneal wound healing versus other inflammatory-dominated conditions. The role of different types of macrophages is also discussed, including how stromal macrophages with anti-inflammatory phenotypes communicate with corneal nerves to provide neuroprotection, while macrophages with pro-inflammatory phenotypes, along with other infiltrating cells including neutrophils and CD4 + T cells, can be inhibitory to corneal re-innervation. Finally, this review considers the bidirectional interactions between corneal immune cells and corneal nerves, and how leveraging this interaction could represent a potential therapeutic approach for corneal neuropathy.

Original languageEnglish
Article number101105
JournalProgress in Retinal and Eye Research
Early online date19 Jul 2022
Publication statusE-pub ahead of print - 19 Jul 2022

Bibliographical note

Funding Information:
Funding support provided by the National Health and Medical Research Council (HRC, APP1126540 ) and the Australian Government Research Training Program (MW). The authors wish to acknowledge Dr. Alexis Ceecee Britten-Jones for providing the IVCM images in Fig. 2 , and to Dr. Cecilia Naranjo Golborne, Dr Helen Jiao and Stephanie Spiridonidis for their contributions to data collection. The authors acknowledge the Florey Advanced Microscopy Facility at the Florey Institute of Neuroscience & Mental Health Facility for provision of instrumentation, training and general support, and the Biological Optical Microscopy Platform for assistance with 3D image analysis.

Publisher Copyright:
© 2022 Elsevier Ltd


Dive into the research topics of 'Neuroimmune crosstalk in the cornea: The role of immune cells in corneal nerve maintenance during homeostasis and inflammation'. Together they form a unique fingerprint.

Cite this