Neuroimaging in disorders of consciousness: Contributions to diagnosis and prognosis

Conventional assessment of the level of awareness that is retained by a patient with a disorder of consciousness following a brain injury is made on the basis of exhibited behaviors. This is particularly challenging for clinicians who must decide whether a certain behavior, which might be inconsistent or incomplete, reflects a conscious or an unconscious process. These assessments are not only highly subjective, but also dependent upon the ability of the patient to produce an appropriate motor response. Recent developments in neuroimaging techniques can provide a measure of the levels of awareness that these patients may retain, and importantly, they overcome the necessity for these patients to produce detectable movements by instead relying on their adopting appropriate 'mind-sets as instructed by the task. In this article, we review recent advances in this field and discuss how they may accompany behavioral assessments in future in order to provide diagnostic and prognostic information.