Neuroendocrine signalling: Natural variations on a Ca2+ theme

Emil Toescu, G Dayanithi

    Research output: Contribution to journalEditorial

    5 Citations (Scopus)


    This special issue on Ca2+ signalling in neuroendocrine cells is an opportunity to assess, through a range of first-class review articles, the complex world of endocrine signalling, a complexity that is probably best captured by calling it "diversity in unity". The unity comes from the fact that all the endocrine cells are excitable cells, able to generate action potentials and are using Ca2+ as an essential informational molecule, coupling cell stimulation with the activation of secretion, through the exocytotic process. The 'diversity' element, illustrated by almost all the reviews, stems from the modalities employed to achieve the increase in cytosolic Ca2+ signal, the balance between the participation of Ca2+ entry through the plasma membrane voltage-operated Ca2+ channels and the release of Ca2+ from intracellular Ca2+ stores, and the cross-talk between the Ca2+ and cyclic AMP signalling pathways. (C) 2012 Published by Elsevier Ltd.
    Original languageEnglish
    Pages (from-to)207-211
    Number of pages5
    JournalCell Calcium
    Issue number3-4
    Publication statusPublished - 1 Mar 2012


    • Lactotropes
    • Pancreatic islets
    • Hypothalamus
    • Supraoptic nucleus
    • Electrical activity
    • Corticotropes
    • cAMP
    • Oxytocin
    • Second messengers
    • Puriniceptors
    • Anterior pituitary
    • Stimulus-secretion coupling
    • Neurotransmitter/peptide release
    • Gonadotropes
    • Ca2+ clearance
    • Exocytosis
    • Chromaffin cell biology and Ca2+ signalling
    • ATP
    • Neurohypophysis
    • Endocrine cells
    • Transgenic rat model for AVP and OT
    • Vasopressin
    • Neuroendocrinology
    • Chromaffin cells
    • Ca2+ stores
    • Opioids
    • Ca2+ homeostasis


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