Network topology and dynamics in traumatic brain injury

We propose a network approach to clinical translation that defines core behavioral phenotypes of traumatic brain injury (TBI) with respect to damage to specific intrinsic connectivity networks (ICNs). We survey recent approaches to clinical translation from cognitive neuroscience that enhance network function and recovery from brain injury through interventions that deliver targeted (network specific) and global (systemic) effects. A network approach provides insight into the mechanisms of brain injury, linking ICN characteristics to specific profiles of cognitive impairment, providing key neurobiological targets for therapeutic intervention, and motivating new perspectives about the nature of cognitive recovery and rehabilitation in TBI.