Natural Treg in autoimmune diabetes: all present and correct?

Lucy Walker

Research output: Contribution to journalArticle

7 Citations (Scopus)


BACKGROUND: The critical role for regulatory T cells (Treg) in suppressing autoimmune pathology is now well recognised. However, the extent to which defects in regulation can be blamed for the onset of diseases like type 1 diabetes is not clear. OBJECtive: To collate the available data from mouse models and from studies of type 1 diabetes patients, with a view to understanding the status of the natural Treg compartment in this disease setting. RESULTS/CONCLUSION: Available evidence suggests that natural Treg are not under-represented in type 1 diabetes, and that Treg function is only likely to be suboptimal in a subset of patients. Emerging therapeutic strategies that attempt to exploit our knowledge of Treg biology to restore effective immune regulation in type I diabetes are discussed.
Original languageEnglish
Pages (from-to)1691-703
Number of pages13
JournalExpert Opinion on Biological Therapy
Issue number11
Publication statusPublished - 1 Nov 2008


  • mouse models
  • regulatory T cells
  • type 1 diabetes
  • autoimmunity


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