Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide

Adrian Hobbs; Paul Foster; Craig Prescott; Ramona Scotland; Amrita Ahluwalia

doi:10.1161/01.CIR.0000141802.29945.34

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide

Adrian Hobbs, Paul Foster, Craig Prescott, Ramona Scotland, Amrita Ahluwalia

Research output: Contribution to journal › Article › peer-review

109 Citations (Scopus)

Abstract

Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor C (NPR-C), which plays a pivotal role in the regulation of local blood flow. We tested the hypothesis that CNP/NPR-C signaling is a novel regulatory pathway governing coronary blood flow and protecting against I/R injury.

Original language	English
Pages (from-to)	1231-5
Number of pages	5
Journal	Circulation
Volume	110
Issue number	10
DOIs	https://doi.org/10.1161/01.CIR.0000141802.29945.34
Publication status	Published - 30 Aug 2004

Access to Document

10.1161/01.CIR.0000141802.29945.34Licence: None: All rights reserved

Cite this

@article{0695f0f2ae2f4b03bf476098ab5beab0,

title = "Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide",

abstract = "Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor C (NPR-C), which plays a pivotal role in the regulation of local blood flow. We tested the hypothesis that CNP/NPR-C signaling is a novel regulatory pathway governing coronary blood flow and protecting against I/R injury.",

author = "Adrian Hobbs and Paul Foster and Craig Prescott and Ramona Scotland and Amrita Ahluwalia",

year = "2004",

month = aug,

day = "30",

doi = "10.1161/01.CIR.0000141802.29945.34",

language = "English",

volume = "110",

pages = "1231--5",

journal = "Circulation",

issn = "0009-7322",

publisher = "American Heart Association",

number = "10",

}

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury : novel cardioprotective role for endothelium-derived C-type natriuretic peptide. / Hobbs, Adrian; Foster, Paul; Prescott, Craig; Scotland, Ramona; Ahluwalia, Amrita.

In: Circulation, Vol. 110, No. 10, 30.08.2004, p. 1231-5.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury

T2 - novel cardioprotective role for endothelium-derived C-type natriuretic peptide

AU - Hobbs, Adrian

AU - Foster, Paul

AU - Prescott, Craig

AU - Scotland, Ramona

AU - Ahluwalia, Amrita

PY - 2004/8/30

Y1 - 2004/8/30

N2 - Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor C (NPR-C), which plays a pivotal role in the regulation of local blood flow. We tested the hypothesis that CNP/NPR-C signaling is a novel regulatory pathway governing coronary blood flow and protecting against I/R injury.

AB - Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor C (NPR-C), which plays a pivotal role in the regulation of local blood flow. We tested the hypothesis that CNP/NPR-C signaling is a novel regulatory pathway governing coronary blood flow and protecting against I/R injury.

U2 - 10.1161/01.CIR.0000141802.29945.34

DO - 10.1161/01.CIR.0000141802.29945.34

M3 - Article

C2 - 15337698

VL - 110

SP - 1231

EP - 1235

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 10

ER -

Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide

Abstract

Access to Document

Fingerprint

Cite this