Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide

Adrian Hobbs, Paul Foster, Craig Prescott, Ramona Scotland, Amrita Ahluwalia

    Research output: Contribution to journalArticlepeer-review

    109 Citations (Scopus)

    Abstract

    Ischemia/reperfusion (I/R) injury complicates myocardial infarction and stroke by exacerbating tissue damage and increasing risk of mortality. We have recently identified C-type natriuretic peptide (CNP) as an endothelium-derived hyperpolarizing factor in the mesenteric resistance vasculature and described a novel signaling pathway involving activation of natriuretic peptide receptor C (NPR-C), which plays a pivotal role in the regulation of local blood flow. We tested the hypothesis that CNP/NPR-C signaling is a novel regulatory pathway governing coronary blood flow and protecting against I/R injury.
    Original languageEnglish
    Pages (from-to)1231-5
    Number of pages5
    JournalCirculation
    Volume110
    Issue number10
    DOIs
    Publication statusPublished - 30 Aug 2004

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