Nanotoxicology and nanomedicine: the Yin and Yang of nano-bio interactions for the new decade

Olesja Bondarenko; Monika Mortimer; Anne Kahru; Neus Feliu; Ibrahim Javed; Aleksandr Kakinen; Sijie Lin; Tian Xia; Yang Song; Thomas P. Davis; Iseult Lynch; Wolfgang J. Parak; David Tai Leong; Pu Chun Ke; Chunying Chen; Yuliang Zhao

doi:10.1016/j.nantod.2021.101184

Nanotoxicology and nanomedicine: the Yin and Yang of nano-bio interactions for the new decade

Olesja Bondarenko, Monika Mortimer, Anne Kahru, Neus Feliu, Ibrahim Javed, Aleksandr Kakinen, Sijie Lin, Tian Xia, Yang Song, Thomas P. Davis, Iseult Lynch, Wolfgang J. Parak, David Tai Leong, Pu Chun Ke^*, Chunying Chen, Yuliang Zhao

^*Corresponding author for this work

Earth and Environmental Sciences

Research output: Contribution to journal › Review article › peer-review

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Abstract

Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials – the main subjects of nanotoxicology – have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.

Original language	English
Article number	101184
Number of pages	11
Journal	Nano Today
Volume	39
Early online date	13 May 2021
DOIs	https://doi.org/10.1016/j.nantod.2021.101184
Publication status	Published - Aug 2021

Bibliographical note

Funding Information:
This work was supported by Estonian Research Council grant PUT1015 , ERDF project TK134 , the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 835140 and Research Infrastructure Project NanoCommons (grant Agreement No 731032 ), the Australian Research Council Project No. CE140100036 , United States National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number ( U01ES027237 ) as part of the Nanotechnology Health Implications Research (NHIR) Consortium, the NSFC grants #21607115 and #21777116 , and by the Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 - project ID 390715994 . We thank Prof. Marcel Leist for insightful discussion.

Publisher Copyright:
© 2021 Elsevier Ltd

Keywords

Coronavirus
Microbiome
NanoEL
Nanomedicine
Nanotoxicology
Protein corona

ASJC Scopus subject areas

Biotechnology
Bioengineering
Biomedical Engineering
Materials Science(all)
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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BondarenkoO2021NanotoxicologyAccepted author manuscript, 1.27 MBLicence: Creative Commons: Attribution-NonCommercial-NoDerivs (CC BY-NC-ND)

Cite this

Bondarenko, O., Mortimer, M., Kahru, A., Feliu, N., Javed, I., Kakinen, A., Lin, S., Xia, T., Song, Y., Davis, T. P., Lynch, I., Parak, W. J., Leong, D. T., Ke, P. C., Chen, C., & Zhao, Y. (2021). Nanotoxicology and nanomedicine: the Yin and Yang of nano-bio interactions for the new decade. Nano Today, 39, Article 101184. Advance online publication. https://doi.org/10.1016/j.nantod.2021.101184

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title = "Nanotoxicology and nanomedicine: the Yin and Yang of nano-bio interactions for the new decade",

abstract = "Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials – the main subjects of nanotoxicology – have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.",

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author = "Olesja Bondarenko and Monika Mortimer and Anne Kahru and Neus Feliu and Ibrahim Javed and Aleksandr Kakinen and Sijie Lin and Tian Xia and Yang Song and Davis, {Thomas P.} and Iseult Lynch and Parak, {Wolfgang J.} and Leong, {David Tai} and Ke, {Pu Chun} and Chunying Chen and Yuliang Zhao",

note = "Funding Information: This work was supported by Estonian Research Council grant PUT1015 , ERDF project TK134 , the European Union{\textquoteright}s Horizon 2020 research and innovation programme under the Marie Sk{\l}odowska-Curie grant agreement No 835140 and Research Infrastructure Project NanoCommons (grant Agreement No 731032 ), the Australian Research Council Project No. CE140100036 , United States National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number ( U01ES027237 ) as part of the Nanotechnology Health Implications Research (NHIR) Consortium, the NSFC grants #21607115 and #21777116 , and by the Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 - project ID 390715994 . We thank Prof. Marcel Leist for insightful discussion. Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

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AU - Bondarenko, Olesja

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AU - Feliu, Neus

AU - Javed, Ibrahim

AU - Kakinen, Aleksandr

AU - Lin, Sijie

AU - Xia, Tian

AU - Song, Yang

AU - Davis, Thomas P.

AU - Lynch, Iseult

AU - Parak, Wolfgang J.

AU - Leong, David Tai

AU - Ke, Pu Chun

AU - Chen, Chunying

AU - Zhao, Yuliang

N1 - Funding Information: This work was supported by Estonian Research Council grant PUT1015 , ERDF project TK134 , the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 835140 and Research Infrastructure Project NanoCommons (grant Agreement No 731032 ), the Australian Research Council Project No. CE140100036 , United States National Institute of Environmental Health Sciences of the National Institutes of Health under Award Number ( U01ES027237 ) as part of the Nanotechnology Health Implications Research (NHIR) Consortium, the NSFC grants #21607115 and #21777116 , and by the Cluster of Excellence 'Advanced Imaging of Matter' of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 - project ID 390715994 . We thank Prof. Marcel Leist for insightful discussion. Publisher Copyright: © 2021 Elsevier Ltd

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N2 - Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health. Here we show the Yin and Yang relationship between the two fields by highlighting their shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies. We focus on the transferable knowledge between the two fields as nanotoxicological research is moving from pristine to functional nanomaterials, while inorganic nanomaterials – the main subjects of nanotoxicology – have become an emerging source for the development of nanomedicines. We call for a close partnership between the two fields in the new decade, to harness the full potential of nanotechnology for benefiting human health and environmental safety.

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VL - 39

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ER -

Nanotoxicology and nanomedicine: the Yin and Yang of nano-bio interactions for the new decade

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this