NanoSolveIT integration of tools for assessment of human and environmental exposure to nanomaterials

Nikolaos Cheimarios, Sam Harrison, Alexander C.Ø. Jensen, Pantelis Karatzas, Andreas Tsoumanis, Philip Doganis, Periklis Tsiros, David A. Winkler, Stephen Lofts, Keld A. Jensen, Haralambos Sarimveis, Antreas Afantitis, Iseult Lynch, Georgia Melagraki

Research output: Chapter in Book/Report/Conference proceedingChapter


Risk assessment for chemicals including nanomaterials requires information on both the likely exposure to the chemicals, in terms of concentration, duration and form, and their hazard to the organisms they come into contact with. Case-by-case determination of exposure and hazard data for each individual nanomaterial variant is not possible due to the time and cost required, and thus there is a strong incentive to develop computational models that can predict human and environmental exposure to nanomaterials based on a reduced set of input parameters as part of an Integrated Approach to Testing and Assessment. Here we report the integration of two exposure models, one predicting human indoor exposure to nanomaterials (the multibox model) and the other predicting environmental exposure to nanomaterials in freshwater at the catchment scale (the NanoFASE water-soil-organism model). Both were developed in previous research projects, and NanoSolveIT has developed the Graphical User Interfaces and NanoSolveIT Application Programming Interface to allow users to access and run the models easily, either as stand-alone open software or via the NanoSolveIT Cloud platform. This represents the first steps toward establishment of a complete integrated in-silico platform for exposure, hazard, and risk assessment of nanomaterials.

Original languageEnglish
Title of host publicationHandbook of Functionalized Nanomaterials
Subtitle of host publicationEnvironmental Health and Safety: A Volume in Micro and Nano Technologies
EditorsChaudhery Hussain, Vineet Kumar
PublisherElsevier Masson
Number of pages40
ISBN (Electronic)9780128224151
Publication statusPublished - 27 Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 Elsevier Inc. All rights reserved.


  • Environmental exposure
  • Human exposure
  • Nanoinformatics
  • Nanomaterials
  • NanoSolveIT
  • Risk assessment

ASJC Scopus subject areas

  • Engineering(all)
  • Materials Science(all)


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