Nanoparticles of chitosan conjugated to organo-ruthenium complexes

Yanqing Wang; Anaïs Pitto-barry; Abraha Habtemariam; Isolda Romero-canelon; Peter J. Sadler; Nicolas P. E. Barry

doi:10.1039/C6QI00115G

Nanoparticles of chitosan conjugated to organo-ruthenium complexes

Yanqing Wang
, Anaïs Pitto-barry
, Abraha Habtemariam
, Isolda Romero-canelon
, Peter J. Sadler
, Nicolas P. E. Barry

Pharmacy

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

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Abstract

The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.

Original language	English
Pages (from-to)	1058-1064
Journal	Inorganic Chemistry Frontiers
Volume	3
Issue number	8
DOIs	https://doi.org/10.1039/C6QI00115G
Publication status	Published - 21 Jun 2016

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Yang_et_al_Nanoparticles_of_chitosan_Inorganic_Chemistry_Frontiers_2016
Published in Inorganic Chemistry Frontiers on 21/06/2016 DOI: 10.1039/C6QI00115G
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title = "Nanoparticles of chitosan conjugated to organo-ruthenium complexes",

abstract = "The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to \{Ru(p-cymene)Cl\}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.",

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T1 - Nanoparticles of chitosan conjugated to organo-ruthenium complexes

AU - Wang, Yanqing

AU - Pitto-barry, Anaïs

AU - Habtemariam, Abraha

AU - Romero-canelon, Isolda

AU - Sadler, Peter J.

AU - Barry, Nicolas P. E.

PY - 2016/6/21

Y1 - 2016/6/21

N2 - The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.

AB - The synthesis of nanoparticles of conjugates of caffeic acid-modified chitosan with ruthenium arene complexes is described. The chemical structure and physical properties of the nanoparticles were characterised by electronic absorption spectroscopy (UV-vis), Fourier transform infrared spectroscopy (FT-IR), 1H NMR spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray powder diffraction (XRD), and circular dichroism (CD) analysis. The multi-spectral results revealed that caffeic acid is covalently bound to chitosan and chelates to {Ru(p-cymene)Cl}+. The DLS studies indicated that the Ru–caffeic acid modified chitosan nanoparticles are well-defined and of nanometre size. Such well-defined nanocomposites of chitosan and metal complexes might find a range of applications, for example in drug delivery.

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JF - Inorganic Chemistry Frontiers

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Nanoparticles of chitosan conjugated to organo-ruthenium complexes

Abstract

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