NAD + metabolism and function in innate and adaptive immune cells

Rebecca Mann; Victoria Stavrou; Sarah Dimeloe

doi:10.1186/s12950-025-00457-7

NAD + metabolism and function in innate and adaptive immune cells

Rebecca Mann
, Victoria Stavrou
, Sarah Dimeloe^*

^*Corresponding author for this work

Immunology and Immunotherapy

Research output: Contribution to journal › Review article › peer-review

221 Downloads (Pure)

Abstract

Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer.

Original language	English
Article number	30
Number of pages	9
Journal	Journal of inflammation (London, England)
Volume	22
Issue number	1
DOIs	https://doi.org/10.1186/s12950-025-00457-7
Publication status	Published - 1 Aug 2025

Bibliographical note

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1186/s12950-025-00457-7Licence: Creative Commons: Attribution (CC BY)

MannR2025NAD+Final published version, 1.16 MBLicence: Creative Commons: Attribution (CC BY)

Interrogating nicotinamide riboside kinase activity as a key determinant of CD4+ T cell metabolism, fate and function
Lavery, G. (Co-Investigator) & Dimeloe, S. (Principal Investigator)
Medical Research Council
1/08/21 → 30/09/24
Project: Research Councils

Cite this

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title = "NAD + metabolism and function in innate and adaptive immune cells",

abstract = "Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer.",

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AU - Mann, Rebecca

AU - Stavrou, Victoria

AU - Dimeloe, Sarah

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Y1 - 2025/8/1

N2 - Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer.

AB - Nicotinamide adenine dinucleotide (NAD+) plays a central role in cellular metabolism and energy production, supporting many biological processes. Recent studies highlight the significance of NAD + in regulation of immune cell function, with implications for our understanding of immune homeostasis, inflammation, and disease. This review reports our current understanding on the role of NAD + in the immune system, specifically in macrophages and T cells, facilitating their metabolic reprogramming during differentiation and activation. It offers an overview of NAD + biosynthesis within these immune cells, describes its role in the modulation of immune cell metabolism and effector function, and highlights potential therapeutic applications of NAD + modulation in immunological disorders including autoimmune diseases and cancer.

U2 - 10.1186/s12950-025-00457-7

DO - 10.1186/s12950-025-00457-7

M3 - Review article

C2 - 40751253

SN - 1476-9255

VL - 22

JO - Journal of inflammation (London, England)

JF - Journal of inflammation (London, England)

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ER -

NAD + metabolism and function in innate and adaptive immune cells

Abstract

Bibliographical note

UN SDGs

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Interrogating nicotinamide riboside kinase activity as a key determinant of CD4+ T cell metabolism, fate and function

Cite this