N-terminal RASSF family: RASSF7-RASSF10.

N Underhill-Day, Victoria Hill, Farida Latif

Research output: Contribution to journalArticle

47 Citations (Scopus)


Epigenetic inactivation of tumor suppressor genes is a hallmark of cancer development. RASSF1A (Ras Association Domain Family 1 isoform A) tumor suppressor gene is one of the most frequently epigenetically inactivated genes in a wide range of adult and children's cancers and could be a useful molecular marker for cancer diagnosis and prognosis. RASSF1A has been shown to play a role in several biological pathways, including cell cycle control, apoptosis and microtubule dynamics. RASSF2, RASSF4, RASSF5 and RASSF6 are also epigenetically inactivated in cancer but have not been analysed in as wide a range of malignancies as RASSF1A. Recently four new members of the RASSF family were identified these are termed N-Terminal RASSF genes (RASSF7-RASSF10). Molecular and biological analysis of these newer members has just begun. This review highlights what we currently know in respects to structural, functional and molecular properties of the N-Terminal RASSFs.
Original languageEnglish
Pages (from-to)284-92
Number of pages9
JournalEpigenetics : official journal of the DNA Methylation Society
Issue number3
Publication statusPublished - 1 Mar 2011


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