Myocardial Perfusion by Myocardial Contrast Echocardiography and Endothelial Dysfunction in Obstructive Sleep Apnea

Mehmood Butt, Omer Khair, Girish Dwivedi, A Shantsila, Eduard Shantsila, Gregory Lip

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Obstructive sleep apnea is associated with increased cardiovascular morbidity and mortality. We investigated myocardial perfusion using real-time quantitative myocardial contrast echocardiography with concurrent assessment of macrovascular and microvascular endothelial dysfunction in normotensive subjects with moderate-to-severe obstructive sleep apnea, who were compared with hypertensive and healthy subjects, as well as the impact of continuous positive airway pressure treatment on obstructive sleep apnea subjects. We measured flow (hyperemia)-mediated dilation and response to glyceryl trinitrate of brachial artery (ultrasound), cutaneous perfusion responses to acetylcholine and sodium nitroprusside (laser Doppler), pulse wave velocity, and circulating endothelial and endothelial progenitor cells in a total of 108 subjects (n=36 each of matched obstructive sleep apnea, hypertension, and healthy cohorts). Subjects with obstructive sleep apnea and hypertension demonstrated abnormal myocardial perfusion (P
Original languageEnglish
Pages (from-to)417-U177
JournalHypertension
Volume58
Issue number3
DOIs
Publication statusPublished - 1 Sep 2011

Keywords

  • obstructive sleep apnea
  • laser Doppler flowmetry
  • myocardial blood flow reserve
  • myocardial contrast echocardiography
  • continuous positive airway pressure
  • flow-mediated dilatation

Fingerprint

Dive into the research topics of 'Myocardial Perfusion by Myocardial Contrast Echocardiography and Endothelial Dysfunction in Obstructive Sleep Apnea'. Together they form a unique fingerprint.

Cite this