Abstract
The quinolone resistance-determining regions (QRDRs) of the gyrA genes of quinolone-resistant clinical and veterinary salmonella isolates were sequenced. Substitutions analogous to a substitution of a Ser to a Phe at position 83 (Ser83-->Phe) and Asp87-->Gly or Tyr in Escherichia coli were found, as was a single novel mutation outside of the QRDR resulting in Ala119-->Glu. The data suggest that gyrA mutations are associated with quinolone resistance in veterinary and clinical salmonella isolates and that the limits of the QRDR may require revision.
Original language | English |
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Pages (from-to) | 1009-13 |
Number of pages | 5 |
Journal | Antimicrobial Agents and Chemotherapy |
Volume | 40 |
Issue number | 4 |
Publication status | Published - Apr 1996 |
Keywords
- Amino Acid Sequence
- Animals
- Anti-Infective Agents
- Base Sequence
- DNA Gyrase
- DNA Topoisomerases, Type II
- Drug Resistance, Microbial
- Escherichia coli
- Fluoroquinolones
- Humans
- Molecular Sequence Data
- Mutation
- Salmonella
- Sequence Homology