Mutation at condon 45 of AcrR contributes to multiple antibiotic resistance in Escherichia coli

Mark Webber; A Talukder; Laura Piddock

doi:10.1128/AAC.49.10.4390-4392.2005

Mutation at condon 45 of AcrR contributes to multiple antibiotic resistance in Escherichia coli

Mark Webber, A Talukder, Laura Piddock

Immunology and Immunotherapy

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Abstract

Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

Original language	English
Pages (from-to)	4390-92
Number of pages	3
Journal	Antimicrobial Agents and Chemotherapy
Volume	49
DOIs	https://doi.org/10.1128/AAC.49.10.4390-4392.2005
Publication status	Published - 1 Jan 2005

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10.1128/AAC.49.10.4390-4392.2005

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title = "Mutation at condon 45 of AcrR contributes to multiple antibiotic resistance in Escherichia coli",

abstract = "Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.",

author = "Mark Webber and A Talukder and Laura Piddock",

year = "2005",

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doi = "10.1128/AAC.49.10.4390-4392.2005",

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T1 - Mutation at condon 45 of AcrR contributes to multiple antibiotic resistance in Escherichia coli

AU - Webber, Mark

AU - Talukder, A

AU - Piddock, Laura

PY - 2005/1/1

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N2 - Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

AB - Fluoroquinolone-resistant Escherichia coli isolates which overexpressed acrB and had a substitution at amino acid 45 of AcrR were complemented with wild-type acrR. Complementation led to increased sensitivity to ciprofloxacin and to ethidium bromide, suggesting that mutation at amino acid 45 of AcrR contributes to ciprofloxacin resistance.

UR - https://www.scopus.com/pages/publications/25844442529

U2 - 10.1128/AAC.49.10.4390-4392.2005

DO - 10.1128/AAC.49.10.4390-4392.2005

M3 - Article

VL - 49

SP - 4390

EP - 4392

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

ER -

Mutation at condon 45 of AcrR contributes to multiple antibiotic resistance in Escherichia coli

Abstract

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