Mussel-Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy

Amin GhavamiNejad, Arathyram Ramachandra Kurup Sasikala, Afeesh Rajan Unnithan, Reju George Thomas, Yong Yeon Jeong, Mohammad Vatankhah-Varnoosfaderani, Florian J. Stadler, Chan Hee Park, Cheol Sang Kim

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.
Original languageEnglish
Pages (from-to)2867-2875
Number of pages9
JournalAdvanced Functional Materials
Volume25
Issue number19
Early online date30 Mar 2015
DOIs
Publication statusPublished - May 2015

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