TY - JOUR
T1 - Mussel-Inspired Electrospun Smart Magnetic Nanofibers for Hyperthermic Chemotherapy
AU - GhavamiNejad, Amin
AU - Sasikala, Arathyram Ramachandra Kurup
AU - Unnithan, Afeesh Rajan
AU - Thomas, Reju George
AU - Jeong, Yong Yeon
AU - Vatankhah-Varnoosfaderani, Mohammad
AU - Stadler, Florian J.
AU - Park, Chan Hee
AU - Kim, Cheol Sang
PY - 2015/5
Y1 - 2015/5
N2 - A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.
AB - A method for the versatile synthesis of novel, mussel-inspired, electrospun nanofibers with catechol moieties is reported. These mussel-inspired nanofibers are used to bind iron oxide nanoparticles (IONPs) and the borate-containing anticancer drug Bortezomib (BTZ) through a catechol metal binding mechanism adapted from nature. These smart nanofibers exhibit a unique conjugation of Bortezomib to their 1, 2-benzenediol (catechol) moieties for enabling a pH-dependent drug delivery towards the cancer cells and the IONPs via strong coordination bonds for exploiting the repeated application of hyperthermia. Thus the synergistic anticancer effect of these mussel-inspired magnetic nanofibers were tested in vitro for the repeated application of hyperthermia along with the chemotherapy and found that the drug-bound catecholic magnetic nanofibers exhibited excellent therapeutic efficacy for potential anticancer treatment.
U2 - 10.1002/adfm.201500389
DO - 10.1002/adfm.201500389
M3 - Article
SN - 1616-301X
VL - 25
SP - 2867
EP - 2875
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 19
ER -
