Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian Cooper; RJ Cox; J Crosby; MP Crump; Joanne Hothersall; W Laosripaiboon; TJ Simpson; Christopher Thomas

doi:10.1039/b414781b

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Sian Cooper, RJ Cox, J Crosby, MP Crump, Joanne Hothersall, W Laosripaiboon, TJ Simpson, Christopher Thomas

Biosciences

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

Original language	English
Pages (from-to)	1179-1181
Number of pages	3
Journal	Chemical Communications
Issue number	9
DOIs	https://doi.org/10.1039/b414781b
Publication status	Published - 1 Jan 2005

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title = "Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster",

abstract = "Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.",

author = "Sian Cooper and RJ Cox and J Crosby and MP Crump and Joanne Hothersall and W Laosripaiboon and TJ Simpson and Christopher Thomas",

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AU - Cooper, Sian

AU - Cox, RJ

AU - Crosby, J

AU - Crump, MP

AU - Hothersall, Joanne

AU - Laosripaiboon, W

AU - Simpson, TJ

AU - Thomas, Christopher

PY - 2005/1/1

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N2 - Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

AB - Mutation of the mupW gene in the mupirocin biosynthetic gene cluster in Pseudomonas fluorescens results in efficient production of a novel pseudomonic acid metabolite, mupirocin W, which lacks the characteristic tetrahydropyran ring, and reveals the role of the mupW gene in pseudomonic acid biosynthesis.

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DO - 10.1039/b414781b

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SN - 1364-548X

SP - 1179

EP - 1181

JO - Chemical Communications

JF - Chemical Communications

IS - 9

ER -

Mupirocin W, a novel pseudomonic acid produced by targeted mutation of the mupirocin biosynthetic gene cluster

Abstract

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