Multispectral, non-contact diffuse optical tomography of healthy human finger joints

Daniel Lighter, James Hughes, Iain Styles, Andrew Filer, Hamid Dehghani

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
127 Downloads (Pure)

Abstract

Rheumatoid arthritis (RA) is an inflammatory joint disease often affecting the hands, which if untreated causes disability. Diffuse optical tomography (DOT) provides information about underlying functional properties of biological tissue. To detect pathophysiological changes in inflamed RA joints, a good understanding of baseline values for healthy subjects is first required. Finger joints from healthy subjects were imaged using a non-contact, multispectral,
continuous wave DOT system, recovering physiological parameters of oxygen saturation, total haemoglobin, water concentration and scatter amplitude. Reconstructed values across the cohort demonstrated good consistency between finger joints from the same participant, with greater variation seen between subjects.
Original languageEnglish
Pages (from-to)1445-1460
Number of pages16
JournalBiomedical Optics Express
Volume9
Issue number4
DOIs
Publication statusPublished - 1 Apr 2018

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