Multiple Myeloma with Monoclonal Free IgG3 Heavy Chains and Free Kappa Light Chains

Alex Richter, S Harding, A Huissoon, Mark Drayson, Guy Pratt

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We describe the case of a 34-year-old gentleman investigated for persistent neutropaenia following two episodes of pneumonia. Specialist investigations led to the diagnosis of multiple myeloma (MM) producing a truncated monoclonal gamma(3) heavy chain (HC) immunoglobulin molecule unattached to a light chain (LC) with atypical features for both MM and HC disease. Western blot showed gamma 3HC was truncated with a large deletion (75 kDa). Flow cytometry of the bone marrow aspirate revealed an unusual staining pattern. This plasma cell dyscrasia was also unusual in that a subpopulation (30%) secreted large quantities of free LC (FLC) as well as truncated IgG HC. This is the first description, investigation and treatment of MM with a plasma cell population producing truncated gamma 3HC and kappa FLC M-proteins and illustrates a number of unique immunological and clinical features. Copyright (C) 2010 S. Karger AG, Basel
Original languageEnglish
Pages (from-to)158-161
Number of pages4
JournalActa Haematologica
Volume123
Issue number3
DOIs
Publication statusPublished - 1 Apr 2010

Keywords

  • Heavy chain disease
  • Light chains
  • Truncation in heavy chains
  • Multiple myeloma
  • Immunoglobulins

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