Keyphrases
Ligand-dependent
100%
Active Sites
100%
Cytochrome P450 (CYP450)
100%
Multiple Ligands
100%
CYP2C9
100%
Protein Surface
40%
G-loop
40%
Molecular Dynamics Simulation
20%
Hydrogen Bonds (H-bonds)
20%
Aromatic Residues
20%
Human Liver
20%
Positively Charged
20%
Charged Residue
20%
Binding Properties
20%
Liver-specific
20%
Cytochrome P450 Monooxygenase
20%
Substrate Access
20%
Two-pathway
20%
Drug Metabolism
20%
Protein Features
20%
Deeply Buried
20%
Product Release
20%
Multiple Tunnels
20%
Exit Routes
20%
Multiple Routes
20%
Access Control
20%
Motion Control
20%
Cytochrome P450 Inhibition
20%
Biochemistry, Genetics and Molecular Biology
Active Site
100%
Cytochrome P450
100%
CYP2C9
100%
Hydrogen Bond
14%
Conformation
14%
Crystal Structure
14%
Motion
14%
Unspecific Monooxygenase
14%
Drug Metabolism
14%
Pharmacology, Toxicology and Pharmaceutical Science
Cytochrome P450
100%
CYP2C9
100%
Hydrogen Bond
14%
Unspecific Monooxygenase
14%
Drug Metabolism
14%
Immunology and Microbiology
Cytochrome P450
100%
Conformation
12%
Motion
12%
Crystal Structure
12%
Hydrogen Bond
12%
Drug Metabolism
12%
Monooxygenase
12%