Multiple depositions of Ag nanoparticles on chemically modified agarose films for surface-enhanced Raman spectroscopy

Wen Lei Zhai, Da Wei Li, Lu Lu Qu, John S. Fossey, Yi Tao Long

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

A facile and cost-effective approach for the preparation of a surface-enhanced Raman spectroscopy (SERS) substrate through constructing silver nanoparticle/3-aminopropyltriethoxysilane/agarose films (Ag NPs/APTES/Agar film) on various solid supports is described. The SERS performance of the substrate was systematically investigated, revealing a maximum SERS intensity with four layers of the Ag NP deposition. The enhancement factor of the developed substrate was calculated as 1.5 × 10 7 using rhodamine 6G (R6G) as the probe molecule, and the reproducibility of the SERS signals was established. A high throughput screening platform was designed, manufactured and implemented which utilised the ability to cast agarose to assemble arrays. Quantitative analysis of 4-aminobenzoic acid (4-ABA) and 4-aminothiophenol (4-ATP) was achieved over a ∼0.5 nM-0.1 μM range.

Original languageEnglish
Pages (from-to)137-142
Number of pages6
JournalNanoscale
Volume4
Issue number1
DOIs
Publication statusPublished - 7 Jan 2012

ASJC Scopus subject areas

  • Materials Science(all)

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