Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy

Chengchao Chu; Jingwen Yu; En Ren; Shangkun Ou; Yunming Zhang; Yiming Wu; Han Wu; Yang Zhang; Jing Zhu; Qixuan Dai; Xiaoyong Wang; Qingliang Zhao; Wei Li; Zuguo Liu; Xiaoyuan Chen; Gang Liu

doi:10.1002/advs.202000346

Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy

Chengchao Chu^*, Jingwen Yu, En Ren, Shangkun Ou, Yunming Zhang, Yiming Wu, Han Wu, Yang Zhang, Jing Zhu, Qixuan Dai, Xiaoyong Wang, Qingliang Zhao, Wei Li^*, Zuguo Liu, Xiaoyuan Chen, Gang Liu^*

^*Corresponding author for this work

Biomedical Sciences

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Abstract

Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)-guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)-based nanocomposite (R-s-ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R-s-ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti-CNV treatment-driven changes in the blood vessels are assessed by real-time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. The treatment leads to the efficient inhibition of CNV with faint damages to normal tissues.

Original language	English
Article number	2000346
Number of pages	7
Journal	Advanced Science
Volume	7
Issue number	14
Early online date	29 May 2020
DOIs	https://doi.org/10.1002/advs.202000346
Publication status	Published - 22 Jul 2020

Bibliographical note

Acknowledgements
C.C., J.Y. and E.R. contributed equally to this work. This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201 and 2016YFC0106900), the National Natural Science Foundation of China (NSFC) (81901876, 81925019, 81801817, 81603015, and U1705281), the Fundamental Research Funds for the Central Universities (20720190088 and 20720200019), the Program for New Century Excellent Talents in University, China (NCET-13-0502) and China Postdoctoral Science Foundation Funded Project (K6419001). All animal experiments were approved by the Animal Management and Ethics Committee of Xiamen University.

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@article{410d1daf6943464e9801c6c53753753f,

title = "Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy",

abstract = "Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)-guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)-based nanocomposite (R-s-ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R-s-ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti-CNV treatment-driven changes in the blood vessels are assessed by real-time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. The treatment leads to the efficient inhibition of CNV with faint damages to normal tissues.",

author = "Chengchao Chu and Jingwen Yu and En Ren and Shangkun Ou and Yunming Zhang and Yiming Wu and Han Wu and Yang Zhang and Jing Zhu and Qixuan Dai and Xiaoyong Wang and Qingliang Zhao and Wei Li and Zuguo Liu and Xiaoyuan Chen and Gang Liu",

note = "Acknowledgements C.C., J.Y. and E.R. contributed equally to this work. This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201 and 2016YFC0106900), the National Natural Science Foundation of China (NSFC) (81901876, 81925019, 81801817, 81603015, and U1705281), the Fundamental Research Funds for the Central Universities (20720190088 and 20720200019), the Program for New Century Excellent Talents in University, China (NCET-13-0502) and China Postdoctoral Science Foundation Funded Project (K6419001). All animal experiments were approved by the Animal Management and Ethics Committee of Xiamen University.",

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doi = "10.1002/advs.202000346",

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T1 - Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization

T2 - A Non-Invasive and Safe Strategy

AU - Chu, Chengchao

AU - Yu, Jingwen

AU - Ren, En

AU - Ou, Shangkun

AU - Zhang, Yunming

AU - Wu, Yiming

AU - Wu, Han

AU - Zhang, Yang

AU - Zhu, Jing

AU - Dai, Qixuan

AU - Wang, Xiaoyong

AU - Zhao, Qingliang

AU - Li, Wei

AU - Liu, Zuguo

AU - Chen, Xiaoyuan

AU - Liu, Gang

N1 - Acknowledgements C.C., J.Y. and E.R. contributed equally to this work. This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201 and 2016YFC0106900), the National Natural Science Foundation of China (NSFC) (81901876, 81925019, 81801817, 81603015, and U1705281), the Fundamental Research Funds for the Central Universities (20720190088 and 20720200019), the Program for New Century Excellent Talents in University, China (NCET-13-0502) and China Postdoctoral Science Foundation Funded Project (K6419001). All animal experiments were approved by the Animal Management and Ethics Committee of Xiamen University.

PY - 2020/7/22

Y1 - 2020/7/22

N2 - Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)-guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)-based nanocomposite (R-s-ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R-s-ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti-CNV treatment-driven changes in the blood vessels are assessed by real-time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. The treatment leads to the efficient inhibition of CNV with faint damages to normal tissues.

AB - Corneal neovascularization (CNV) is one of the main factors that induce blindness worldwide. However, current medical treatments cannot achieve non-invasive and safe inhibition of CNV. A noninvasive photoacoustic imaging (PAI)-guided method is purposed for the regression of CNV. PAI can monitor the oxygen saturation of cornea blood vessels through the endogenous contrast of hemoglobin and trace administrated drugs by themselves as exogenous contrast agents. An indocyanine green (ICG)-based nanocomposite (R-s-ICG) is prepared for CNV treatment via eye drops and subconjunctival injections. It is demonstrated that R-s-ICG can enrich corneal tissues and pathological blood vessels rapidly with minor residua in normal eyeball tissues. Anti-CNV treatment-driven changes in the blood vessels are assessed by real-time multimodal PAI in vivo, and then a safe laser irradiation strategy through the canthus is developed for phototherapy and gene therapy synergistic treatment. The treatment leads to the efficient inhibition of CNV with faint damages to normal tissues.

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DO - 10.1002/advs.202000346

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ER -

Multimodal Photoacoustic Imaging-Guided Regression of Corneal Neovascularization: A Non-Invasive and Safe Strategy

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