Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics

H. Ali-Boucetta; K. T. Al-Jamal; K. Kostarelos

Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics

H. Ali-Boucetta^*, K. T. Al-Jamal, K. Kostarelos

^*Corresponding author for this work

Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

The potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.

Original language	English
Title of host publication	Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Pages	16-18
Number of pages	3
Publication status	Published - 2008
Event	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 - Quebec City, QC, United States Duration: 1 Jun 2008 → 5 Jun 2008

Publication series

Name	Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008
Volume	2

Conference

Conference	2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008
Country/Territory	United States
City	Quebec City, QC
Period	1/06/08 → 5/06/08

Keywords

Cancer
Carbon nanotubes
Doxorubicin
Supramolecular complexes

ASJC Scopus subject areas

Mechanical Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

Ali-Boucetta, H., Al-Jamal, K. T., & Kostarelos, K. (2008). Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008 (pp. 16-18). (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).

Ali-Boucetta, H. ; Al-Jamal, K. T. ; Kostarelos, K. / Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. pp. 16-18 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008).

@inproceedings{855c84c66eb249bc9c245f75562b153b,

title = "Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics",

abstract = "The potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.",

keywords = "Cancer, Carbon nanotubes, Doxorubicin, Supramolecular complexes",

author = "H. Ali-Boucetta and Al-Jamal, {K. T.} and K. Kostarelos",

year = "2008",

language = "English",

isbn = "9781420085075",

series = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",

pages = "16--18",

booktitle = "Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008",

note = "2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008 ; Conference date: 01-06-2008 Through 05-06-2008",

}

Ali-Boucetta, H, Al-Jamal, KT & Kostarelos, K 2008, Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. in Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008, vol. 2, pp. 16-18, 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008, Quebec City, QC, United States, 1/06/08.

Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. / Ali-Boucetta, H.; Al-Jamal, K. T.; Kostarelos, K.
Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. p. 16-18 (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008; Vol. 2).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics

AU - Ali-Boucetta, H.

AU - Al-Jamal, K. T.

AU - Kostarelos, K.

PY - 2008

Y1 - 2008

N2 - The potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.

AB - The potential of carbon nanotubes as carriers and delivery vectors for anticancer drugs was investigated. Herein, we propose MWNT-doxorubicin supramolecular complexes that can be developed for cancer therapy. The formation of such complexes is evidenced by a sharp decrease in the intensity of the doxorubicin fluorescence spectrum and takes place via π-π interactions with the MWNT backbone. In addition, the structural characteristics of the CNT-doxorubicin complexes were examined by transmission electron microscopy and showed well dispersed pluronic wrapped MWNT but clustered MWNT-doxorubicin structures. Very interestingly the doxorubicinMWNT complexes exhibit enhanced cytotoxic activity compared to both doxorubicin alone and doxorubicin-pluronic complexes.

KW - Cancer

KW - Carbon nanotubes

KW - Doxorubicin

KW - Supramolecular complexes

UR - http://www.scopus.com/inward/record.url?scp=52649167825&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:52649167825

SN - 9781420085075

SN - 9781420085044

T3 - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

SP - 16

EP - 18

BT - Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008

T2 - 2008 NSTI Nanotechnology Conference and Trade Show, NSTI Nanotech 2008 Joint Meeting, Nanotechnology 2008

Y2 - 1 June 2008 through 5 June 2008

ER -

Ali-Boucetta H, Al-Jamal KT, Kostarelos K. Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics. In Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008. 2008. p. 16-18. (Technical Proceedings of the 2008 NSTI Nanotechnology Conference and Trade Show, NSTI-Nanotech, Nanotechnology 2008).

Multi-walled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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