Multi-omic spatial profiling reveals the unique virus-driven immune landscape of COVID-19 placentitis

Keyphrases

• Virus 100%
• COVID-19 100%
• Multi-omics 100%
• Spatial Profiling 100%
• Immune Landscape 100%
• Placentitis 100%
• SARS-CoV-2 Infection 75%
• Placenta 50%
• Macrophages 25%
• Microenvironment 25%
• Interferon-α (IFN-α) 25%
• Trophoblast 25%
• Extravillous Trophoblast 25%
• Inverse Correlation 25%
• Immunopathology 25%
• Rare Complication 25%
• Disease Duration 25%
• Angiotensin-converting Enzyme 2 (ACE2) 25%
• Viral Clearance 25%
• Viral Load 25%
• Loading Time 25%
• Viral Etiology 25%
• Programmed Death-ligand 1 (PD-L1) 25%
• Viral Disease 25%
• Maternal Side 25%
• COVID-19 Infection 25%
• Maternal COVID-19 25%
• Placental Infection 25%
• Quantitative Spatial Analysis 25%
• T Cell Exclusion 25%
• Spatial Characterization 25%

Immunology and Microbiology

• Multi-Omics 100%
• Immune Landscape 100%
• COVID-19 100%
• Severe Acute Respiratory Syndrome Coronavirus 2 100%
• Virus 100%
• Trophoblast 50%
• Placenta 50%
• T Cell 25%
• Macrophage 25%
• Viral Load 25%
• interferon 25%
• Viral Clearance 25%
• Immunopathology 25%