Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas

Luis G Carvajal-Carmona; Ann G Zauber; Angela M Jones; Kimberley Howarth; Jiping Wang; Timothy Cheng; Robert Riddell; Angel Lanas; Dion Morton; Monica M Bertagnolli; Ian Tomlinson; APC Trial Collaborators

doi:10.1053/j.gastro.2012.09.016

Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas

Luis G Carvajal-Carmona, Ann G Zauber, Angela M Jones, Kimberley Howarth, Jiping Wang, Timothy Cheng, Robert Riddell, Angel Lanas, Dion Morton, Monica M Bertagnolli, Ian Tomlinson, APC Trial Collaborators

Cancer and Genomic Sciences

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.

Original language	English
Pages (from-to)	53-55
Journal	Gastroenterology
Volume	144
Issue number	1
DOIs	https://doi.org/10.1053/j.gastro.2012.09.016
Publication status	Published - Jan 2012

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Carvajal-Carmona, L. G., Zauber, A. G., Jones, A. M., Howarth, K., Wang, J., Cheng, T., Riddell, R., Lanas, A., Morton, D., Bertagnolli, M. M., Tomlinson, I., & APC Trial Collaborators (2012). Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas. Gastroenterology, 144(1), 53-55. https://doi.org/10.1053/j.gastro.2012.09.016

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title = "Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas",

abstract = "Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.",

author = "Carvajal-Carmona, {Luis G} and Zauber, {Ann G} and Jones, {Angela M} and Kimberley Howarth and Jiping Wang and Timothy Cheng and Robert Riddell and Angel Lanas and Dion Morton and Bertagnolli, {Monica M} and Ian Tomlinson and {APC Trial Collaborators}",

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doi = "10.1053/j.gastro.2012.09.016",

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Carvajal-Carmona, LG, Zauber, AG, Jones, AM, Howarth, K, Wang, J, Cheng, T, Riddell, R, Lanas, A, Morton, D, Bertagnolli, MM, Tomlinson, I & APC Trial Collaborators 2012, 'Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas', Gastroenterology, vol. 144, no. 1, pp. 53-55. https://doi.org/10.1053/j.gastro.2012.09.016

TY - JOUR

T1 - Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas

AU - Carvajal-Carmona, Luis G

AU - Zauber, Ann G

AU - Jones, Angela M

AU - Howarth, Kimberley

AU - Wang, Jiping

AU - Cheng, Timothy

AU - Riddell, Robert

AU - Lanas, Angel

AU - Morton, Dion

AU - Bertagnolli, Monica M

AU - Tomlinson, Ian

AU - APC Trial Collaborators

PY - 2012/1

Y1 - 2012/1

N2 - Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.

AB - Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.

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DO - 10.1053/j.gastro.2012.09.016

M3 - Article

C2 - 22999960

VL - 144

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JO - Gastroenterology

JF - Gastroenterology

IS - 1

ER -

Much of the Population Genetic Risk of Colorectal Cancer Is Likely to Be Mediated Through Susceptibility to Adenomas

Abstract

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