MUC 1: A genetic susceptibility to infertility?

AW Horne, JO White, RA Margara, R Williams, RM Winstone, El-Nasir Lalani

    Research output: Contribution to journalArticle

    39 Citations (Scopus)


    In man and some animals regulation of embryo implantation by endometrial expression of the highly polymorphic MUC 1 mucin has been suggested. We assessed the polymorphism of MUC 1 in women known to be fertile and those with infertility due to suspected failure of embryo implantation. The median of the lower allele size in the infertile group was only 2.5 kb compared with 3.4 kb in the fertile group (p=0.0029, difference 0.9, [95% CI 0.1-1.3]). Women with unexplained infertility might have a genetic susceptibility to failure of embryo implantation due to small MUC 1 allele size.
    Original languageEnglish
    Pages (from-to)1336-1337
    Number of pages2
    Publication statusPublished - 28 Apr 2001


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