Mortality in systemic lupus erythematosus

S Bernatsky; JF Boivin; L Joseph; S Manzi; E Ginzler; DD Gladman; M Urowitz; PR Fortin; M Petri; S Barr; Caroline Gordon; D Isenberg

doi:10.1002/art.21955

Mortality in systemic lupus erythematosus

S Bernatsky, JF Boivin, L Joseph, S Manzi, E Ginzler, DD Gladman, M Urowitz, PR Fortin, M Petri, S Barr, Caroline Gordon, D Isenberg

Immunology and Immunotherapy

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Abstract

OBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration

Original language	English
Pages (from-to)	2550-2557
Number of pages	8
Journal	Arthritis & Rheumatism
Volume	54
Issue number	8
DOIs	https://doi.org/10.1002/art.21955
Publication status	Published - 1 Aug 2006

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abstract = "OBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration ",

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T1 - Mortality in systemic lupus erythematosus

AU - Bernatsky, S

AU - Boivin, JF

AU - Joseph, L

AU - Manzi, S

AU - Ginzler, E

AU - Gladman, DD

AU - Urowitz, M

AU - Fortin, PR

AU - Petri, M

AU - Barr, S

AU - Gordon, Caroline

AU - Isenberg, D

PY - 2006/8/1

Y1 - 2006/8/1

N2 - OBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration

AB - OBJECTIVE: To examine mortality rates in the largest systemic lupus erythematosus (SLE) cohort ever assembled. METHODS: Our sample was a multisite international SLE cohort (23 centers, 9,547 patients). Deaths were ascertained by vital statistics registry linkage. Standardized mortality ratio (SMR; ratio of deaths observed to deaths expected) estimates were calculated for all deaths and by cause. The effects of sex, age, SLE duration, race, and calendar-year periods were determined. RESULTS: The overall SMR was 2.4 (95% confidence interval 2.3-2.5). Particularly high mortality was seen for circulatory disease, infections, renal disease, non-Hodgkin's lymphoma, and lung cancer. The highest SMR estimates were seen in patient groups characterized by female sex, younger age, SLE duration

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JO - Arthritis & Rheumatism

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Mortality in systemic lupus erythematosus

Abstract

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