TY - JOUR
T1 - Mortality from cardiovascular disease in relation to magnetic field exposure: findings from a study of UK electricity generation and transmission workers, 1973-1997
AU - Sorahan, Thomas
AU - Nichols, Linda
PY - 2004/1/1
Y1 - 2004/1/1
N2 - BACKGROUND: Experimental and epidemiological studies have indicated that magnetic field exposure might influence heart rate variability and consequent risks of arrhythmia related deaths. METHODS: The mortality experience of a cohort of 83,997 employees of the former Central Electricity Generating Board (CEGB) of England and Wales was investigated for the period 1973-1997. Cohort members were employed for at least 6 months from 1973 to 1982. Computerized work histories were available for 79,972 study subjects for the period 1971-1993. Detailed calculations had been performed by others to enable a novel assessment to be made of exposures to magnetic fields. Two analytical approaches were used, indirect standardization (n = 83,997) and Poisson regression (n = 79,972). RESULTS: Based on serial mortality rates for England and Wales, deaths from four categories of cardiovascular disease were below expectation: arrhythmia-related disease (ICD-9 426-7), observed (obs) 32, expected (exp) 43.5, standardized mortality ratio (SMR) 74; acute myocardial infarction (ICD-9 410), obs 3,320, exp 3878.3, SMR 86; atherosclerosis (ICD-9 440), obs 25, exp 39.2, SMR 64; chronic/sub-acute coronary disease (ICD-9 411-414), obs 1,552, exp 2021.7, SMR 77). No statistically significant trends were shown for risks of any of these four disease groupings to increase either with lifetime cumulative exposure to magnetic fields or with such exposures received in the most recent 5 years. CONCLUSIONS: There are no discernible excess risks of mortality from cardiovascular diseases as a consequence of occupational exposure to magnetic fields in UK electricity generation and transmission workers.
AB - BACKGROUND: Experimental and epidemiological studies have indicated that magnetic field exposure might influence heart rate variability and consequent risks of arrhythmia related deaths. METHODS: The mortality experience of a cohort of 83,997 employees of the former Central Electricity Generating Board (CEGB) of England and Wales was investigated for the period 1973-1997. Cohort members were employed for at least 6 months from 1973 to 1982. Computerized work histories were available for 79,972 study subjects for the period 1971-1993. Detailed calculations had been performed by others to enable a novel assessment to be made of exposures to magnetic fields. Two analytical approaches were used, indirect standardization (n = 83,997) and Poisson regression (n = 79,972). RESULTS: Based on serial mortality rates for England and Wales, deaths from four categories of cardiovascular disease were below expectation: arrhythmia-related disease (ICD-9 426-7), observed (obs) 32, expected (exp) 43.5, standardized mortality ratio (SMR) 74; acute myocardial infarction (ICD-9 410), obs 3,320, exp 3878.3, SMR 86; atherosclerosis (ICD-9 440), obs 25, exp 39.2, SMR 64; chronic/sub-acute coronary disease (ICD-9 411-414), obs 1,552, exp 2021.7, SMR 77). No statistically significant trends were shown for risks of any of these four disease groupings to increase either with lifetime cumulative exposure to magnetic fields or with such exposures received in the most recent 5 years. CONCLUSIONS: There are no discernible excess risks of mortality from cardiovascular diseases as a consequence of occupational exposure to magnetic fields in UK electricity generation and transmission workers.
KW - arrhythmia
KW - cardiovascular disease
KW - magnetic fields
KW - cohort mortality study
KW - electricity generation and transmission
UR - http://www.scopus.com/inward/record.url?scp=0346059680&partnerID=8YFLogxK
U2 - 10.1002/ajim.10314
DO - 10.1002/ajim.10314
M3 - Article
C2 - 14691973
SN - 1097-0274
SN - 1097-0274
SN - 1097-0274
SN - 1097-0274
VL - 45
SP - 93
EP - 102
JO - American Journal of Industrial Medicine
JF - American Journal of Industrial Medicine
ER -