TY - GEN
T1 - Monoclonal B-Cell Lymphocytosis (MBL) Is a Precursor State for Chronic Lymphocytic Leukemia (CLL) with 1% Progression Per Year.
AU - Rawstron, Andy
AU - Bennet, Fiona
AU - O'Connor, Sheila
AU - Kwok, Marwan Cheng Kuang
AU - Fenton, James
AU - Plummer, Marieth
AU - de Tute, Ruth
AU - Owen, Roger
AU - Richard, Steven
AU - Jack, Andrew
AU - Hillmen, Peter
PY - 2007/11/16
Y1 - 2007/11/16
N2 - The 2007 IWCLL guidelines indicate that a diagnosis of Chronic Lymphocytic Leukemia (CLL) requires a B-cell count above 5,000/μL in the absence of other features; below this level the diagnosis is Monoclonal B-cell Lymphocytosis (MBL). There is little outcome data for MBL patients and it is not clear whether the detection of low levels of CLL cells, seen in 3% of the general population, is of clinical relevance. We have therefore investigated two hospital populations: the first with normal blood counts and no history of cancer; and the second MBL patients referred for investigation of a current or prior lymphocytosis.
AB - The 2007 IWCLL guidelines indicate that a diagnosis of Chronic Lymphocytic Leukemia (CLL) requires a B-cell count above 5,000/μL in the absence of other features; below this level the diagnosis is Monoclonal B-cell Lymphocytosis (MBL). There is little outcome data for MBL patients and it is not clear whether the detection of low levels of CLL cells, seen in 3% of the general population, is of clinical relevance. We have therefore investigated two hospital populations: the first with normal blood counts and no history of cancer; and the second MBL patients referred for investigation of a current or prior lymphocytosis.
UR - http://dx.doi.org/10.1182/blood.v110.11.749.749
U2 - 10.1182/blood.v110.11.749.749
DO - 10.1182/blood.v110.11.749.749
M3 - Conference contribution
VL - 110
T3 - Blood
SP - 749
BT - Blood
PB - American Society of Hematology
ER -
