Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

Mark Sherlock; Aurora Aragon Alonso; Raoul Reulen; John Ayuk; RN Clayton; G Holder; Michael Sheppard; Andrew Bates; Paul Stewart

doi:10.1111/j.1365-2265.2008.03461.x

Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

Mark Sherlock, Aurora Aragon Alonso, Raoul Reulen, John Ayuk, RN Clayton, G Holder, Michael Sheppard, Andrew Bates, Paul Stewart

Research output: Contribution to journal › Article

20 Citations (Scopus)

Abstract

SUMMARY Context: The aims of treatment in patients with acromegaly are to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality and alleviation of symptoms. Objective and methods: Using the West Midlands Acromegaly database (n=501) we investigated the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC), respectively, the degree of discordance between disease activity measured by GH and IGF-I values and the effect of radiotherapy on the above relationships. In total 773 OGTT and 507 GHDC were performed. Results: Basal fasting GH was strongly correlated with nadir/ mean GH on OGTT/GHDC (r=+0.87, p

Original language	English
Journal	Clinical Endocrinology
DOIs	https://doi.org/10.1111/j.1365-2265.2008.03461.x
Publication status	Published - 27 Oct 2008

Access to Document

10.1111/j.1365-2265.2008.03461.x

Cite this

@article{7183e22b1c9b4762af4213d4051b27fe,

title = "Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.",

abstract = "SUMMARY Context: The aims of treatment in patients with acromegaly are to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality and alleviation of symptoms. Objective and methods: Using the West Midlands Acromegaly database (n=501) we investigated the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC), respectively, the degree of discordance between disease activity measured by GH and IGF-I values and the effect of radiotherapy on the above relationships. In total 773 OGTT and 507 GHDC were performed. Results: Basal fasting GH was strongly correlated with nadir/ mean GH on OGTT/GHDC (r=+0.87, p",

author = "Mark Sherlock and {Aragon Alonso}, Aurora and Raoul Reulen and John Ayuk and RN Clayton and G Holder and Michael Sheppard and Andrew Bates and Paul Stewart",

year = "2008",

month = oct,

day = "27",

doi = "10.1111/j.1365-2265.2008.03461.x",

language = "English",

journal = "Clinical Endocrinology",

issn = "1365-2265",

publisher = "Wiley",

}

TY - JOUR

T1 - Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

AU - Sherlock, Mark

AU - Aragon Alonso, Aurora

AU - Reulen, Raoul

AU - Ayuk, John

AU - Clayton, RN

AU - Holder, G

AU - Sheppard, Michael

AU - Bates, Andrew

AU - Stewart, Paul

PY - 2008/10/27

Y1 - 2008/10/27

N2 - SUMMARY Context: The aims of treatment in patients with acromegaly are to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality and alleviation of symptoms. Objective and methods: Using the West Midlands Acromegaly database (n=501) we investigated the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC), respectively, the degree of discordance between disease activity measured by GH and IGF-I values and the effect of radiotherapy on the above relationships. In total 773 OGTT and 507 GHDC were performed. Results: Basal fasting GH was strongly correlated with nadir/ mean GH on OGTT/GHDC (r=+0.87, p

AB - SUMMARY Context: The aims of treatment in patients with acromegaly are to achieve serum GH/ IGF-I concentrations associated with cure or normalisation of mortality and alleviation of symptoms. Objective and methods: Using the West Midlands Acromegaly database (n=501) we investigated the reliability of basal fasting GH in predicting nadir or mean GH during oral glucose tolerance test (OGTT) or growth hormone day curve (GHDC), respectively, the degree of discordance between disease activity measured by GH and IGF-I values and the effect of radiotherapy on the above relationships. In total 773 OGTT and 507 GHDC were performed. Results: Basal fasting GH was strongly correlated with nadir/ mean GH on OGTT/GHDC (r=+0.87, p

U2 - 10.1111/j.1365-2265.2008.03461.x

DO - 10.1111/j.1365-2265.2008.03461.x

M3 - Article

C2 - 19178529

SN - 1365-2265

JO - Clinical Endocrinology

JF - Clinical Endocrinology

ER -

Monitoring disease activity using growth hormone and insulin like growth factor-I in the follow up of 501 patients with acromegaly.

Abstract

Access to Document

Fingerprint

Cite this