Molecular mechanisms of antibiotic resistance

Jessica M A Blair; Mark A Webber; Alison J Baylay; David O Ogbolu; Laura J V Piddock

doi:10.1038/nrmicro3380

Molecular mechanisms of antibiotic resistance

Jessica M A Blair, Mark A Webber, Alison J Baylay, David O Ogbolu, Laura J V Piddock

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

1461 Citations (Scopus)

Abstract

Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.

Original language	English
Pages (from-to)	42-51
Number of pages	10
Journal	Nature Reviews Microbiology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1038/nrmicro3380
Publication status	Published - Jan 2015

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10.1038/nrmicro3380

Unravelling the Network of Regulation of Multidrug Resistance in Salmonella Enterica
Piddock, L. (Principal Investigator) & Busby, S. (Co-Investigator)
Medical Research Council
1/05/09 → 31/12/14
Project: Research Councils

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abstract = "Antibiotic-resistant bacteria that are difficult or impossible to treat are becoming increasingly common and are causing a global health crisis. Antibiotic resistance is encoded by several genes, many of which can transfer between bacteria. New resistance mechanisms are constantly being described, and new genes and vectors of transmission are identified on a regular basis. This article reviews recent advances in our understanding of the mechanisms by which bacteria are either intrinsically resistant or acquire resistance to antibiotics, including the prevention of access to drug targets, changes in the structure and protection of antibiotic targets and the direct modification or inactivation of antibiotics.",

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Molecular mechanisms of antibiotic resistance

Abstract

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Unravelling the Network of Regulation of Multidrug Resistance in Salmonella Enterica

Cite this