Projects per year
The plakin family of cytolinkers interacts with intermediate filaments (IFs) through plakin repeat domain (PRD) and linker modules. Recent structure/function studies have established the molecular basis of envoplakin-PRD and periplakin-linker interactions with vimentin. Both plakin modules share a broad basic groove which recognizes acidic rod elements on IFs, a mechanism that is applicable to other plakin family members. This review postulates a universal IF engagement mechanism that illuminates the specific effects of pathogenic mutations associated with diseases including arrhythmogenic right ventricular cardiomyopathy, and reveals how diverse plakin proteins offer tailored IF tethering to ensure stable, dynamic and regulated cellular structures.
|Journal||Biochimica et Biophysica Acta. Molecular Cell Research|
|Early online date||23 Jul 2020|
|Publication status||Published - 1 Nov 2020|
- Arrhythmogenic right ventricular cardiomyopathy
- Intermediate filament
- Linker module
- Plakin repeat domain
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- 3 Finished
The Molecular Basis of Gamma Delta T Cell Recognition in Health and Disease
1/06/13 → 31/05/21
Structure and Function in Desmosomal Junctions
Overduin, M. & Chidgey, M.
1/02/12 → 31/07/15