Molecular events following activation of muscarinic receptors: the role of inositol phospholipids

L. M. Jones, J. Kirk Ch, Robert H Michell

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Muscarinic cholinergic agonists can provoke a wide variety of physiological responses in target tissues. This can be achieved by mobilisation of calcium from intracellular and extracellular stores. The members of the family of Ca2+-mobilising receptors to which the muscarinic receptor belongs share the ability to provoke a calcium-independent decrease in the concentration of inositol phospholipids. This response is closely coupled to agonist binding and is thus implicated in the mechanism whereby muscarinic and related receptors bring about elevated levels of Ca2+ in cells. Another widespread response to activation of muscarinic receptors is inhibition of adenylate cyclase possibly through direct interaction with a nucleotide regulatory protein. Circumstantial evidence and analogy with α2-adrenergic receptors suggests that adenylate cylase inhibition may be mediated by a different form of the muscarinic receptor to that involved in calcium mobilisation.

Original languageEnglish
Pages (from-to)33-41
Number of pages9
JournalScandinavian Journal of Gastroenterology. Supplement
Issue number72
Publication statusPublished - 1 Jan 1982

ASJC Scopus subject areas

  • Gastroenterology


Dive into the research topics of 'Molecular events following activation of muscarinic receptors: the role of inositol phospholipids'. Together they form a unique fingerprint.

Cite this