Projects per year
Abstract
The transcription factor RUNX1 is essential for correct hematopoietic development; in its absence in the germ line, blood stem cells are not formed. RUNX1 orchestrates dramatic changes in the chromatin landscape at the onset of stem cell formation, which set the stage for both stem self-renewal and further differentiation. However, once blood stem cells are formed, the mutation of the RUNX1 gene is not lethal but can lead to various hematopoietic defects and a predisposition to cancer. Here we summarize the current literature on inherited and acquired RUNX1 mutations, with a particular emphasis on mutations that alter the structure of the RUNX1 protein itself, and place these changes in the context of what is known about RUNX1 function. We also summarize which mutant RUNX1 proteins are actually expressed in cells and discuss the molecular mechanism underlying how such variants reprogram the epigenome setting stem cells on the path to malignancy.
Original language | English |
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Pages (from-to) | 1-12 |
Number of pages | 12 |
Journal | Experimental Hematology |
Volume | 111 |
Early online date | 24 Mar 2022 |
DOIs | |
Publication status | Published - Jul 2022 |
Bibliographical note
Funding Information:SGK, PNC, and CB are funded by Blood Cancer UK (15001) and the Medical Research Council (MR/S021469/1). DJLC is funded by Leukemia UK and the Wellcome Trust.
ASJC Scopus subject areas
- Genetics
- Molecular Biology
- Hematology
- Cancer Research
- Cell Biology
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Dive into the research topics of 'Molecular basis of haematological disease caused by inherited or acquired RUNX1 mutations'. Together they form a unique fingerprint.Projects
- 2 Finished
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Finding therapeutic targets in FLT3-ITD AML using a systems biology approach
1/09/19 → 31/12/23
Project: Research Councils
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Mechanistic insights into aberrant transcriptional programming in acute myeloid leukaemia
1/07/15 → 31/12/21
Project: Research