Projects per year
Abstract
Vascular endothelial cells play a pivotal role in regulating leucocyte recruitment during inflammation, and their responses can be modulated by their local environment, including cells of the tissue stroma. We have developed a model system to examine how the communication between endothelial cells and fibroblasts regulates the recruitment of leucocytes and their subsequent subendothelial fate. Here, we describe a novel co-culture filter-based flow assay and highlight the ability of synovial fibroblasts obtained from chronically inflamed tissue to promote leucocyte recruitment to otherwise 'resting' endothelial cells.
Original language | English |
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Pages (from-to) | 1161-1162 |
Number of pages | 2 |
Journal | Biochemical Society Transactions |
Volume | 35 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Oct 2007 |
Keywords
- leucocyte
- endothelial cell
- stromal cell
- neutrophil
- fibroblast
- adhesion
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Dive into the research topics of 'Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment'. Together they form a unique fingerprint.Projects
- 2 Finished
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MRC Centre For Immune Regulation (Linked to DCDF.RRAK10540) (Linked to 14810 & 14835)
Jenkinson, E. (Principal Investigator)
3/08/09 → 30/09/17
Project: Research Councils
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The Role of Fibroblasts in the Regulation of Leucocyte Retention in Chronic Inflammation
Buckley, C. (Principal Investigator)
1/10/01 → 30/09/06
Project: Research Councils