Modular ‘click’ sensors for zinc and their application in vivo

Kajally Jobe; Caroline H. Brennan; Majid Motevalli; Stephen M. Goldup; Michael Watkinson

doi:10.1039/c1cc11213a

Modular ‘click’ sensors for zinc and their application in vivo

Kajally Jobe
, Caroline H. Brennan
, Majid Motevalli
, Stephen M. Goldup^*
, Michael Watkinson

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

Original language	English
Pages (from-to)	6036-6038
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	21
DOIs	https://doi.org/10.1039/c1cc11213a
Publication status	Published - 16 May 2011

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c1cc11213a

Cite this

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title = "Modular {\textquoteleft}click{\textquoteright} sensors for zinc and their application in vivo",

abstract = "Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a {\textquoteleft}click{\textquoteright} approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.",

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AU - Brennan, Caroline H.

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AU - Goldup, Stephen M.

AU - Watkinson, Michael

PY - 2011/5/16

Y1 - 2011/5/16

N2 - Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

AB - Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

UR - https://www.scopus.com/pages/publications/79956091590

U2 - 10.1039/c1cc11213a

DO - 10.1039/c1cc11213a

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SP - 6036

EP - 6038

JO - Chemical Communications

JF - Chemical Communications

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Modular ‘click’ sensors for zinc and their application in vivo

Abstract

ASJC Scopus subject areas

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