Modular ‘click’ sensors for zinc and their application in vivo

Kajally Jobe, Caroline H. Brennan, Majid Motevalli, Stephen M. Goldup*, Michael Watkinson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

79 Citations (Scopus)

Abstract

Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a ‘click’ approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model.

Original languageEnglish
Pages (from-to)6036-6038
Number of pages3
JournalChemical Communications
Volume47
Issue number21
DOIs
Publication statusPublished - 16 May 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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