Models and computational strategies linking physiological response to molecular networks from large-scale data.

F Ortega, K Sameith, Nil Turan Jurdzinski, R Compton, V Trevino, M Vannucci, Francesco Falciani

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

An important area of research in systems biology involves the analysis and integration of genome-wide functional datasets. In this context, a major goal is the identification of a putative molecular network controlling physiological response from experimental data. With very fragmentary mechanistic information, this is a challenging task. A number of methods have been developed, each one with the potential to address an aspect of the problem. Here, we review some of the most widely used methodologies and report new results in support of the usefulness of modularization and other modelling techniques in identifying components of the molecular networks that are predictive of physiological response. We also discuss how system identification in biology could be approached, using a combination of methodologies that aim to reconstruct the relationship between molecular pathways and physiology at different levels of the organizational complexity of the molecular network.
Original languageEnglish
Pages (from-to)3067-89
Number of pages23
JournalPhilosophical Transactions of The Royal Society A Mathematical Physical and Engineering Sciences
Volume366
Issue number1878
DOIs
Publication statusPublished - 13 Sep 2008

Keywords

  • statistical modelling
  • systems biology
  • network inference
  • functional modules

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