Modelling of the flow of cohesive powders during pharmaceutical tabletting

Chuan-yu Wu, Yu Guo

Research output: Contribution to journalArticle


Flow of cohesive powders during the die filling stage of pharmaceutical tabletting was analysed using a coupled discrete element method and computational fluid dynamics (DEM/CFD), in which a two-way air-particle interaction coupling mechanism was established for modelling the effect of the presence of air and the JKR theory was incorporated to simulate the interaction between cohesive particles. It has been found that for cohesive powders intermittent flow occurs, in which powder flows as chunks of agglomerates. In addition, make-up of vessel walls, arching and air entrapment can be induced.
Original languageEnglish
Pages (from-to)1450-1451
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Issue number10
Publication statusPublished - 1 Oct 2010


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