Modern engines feature a considerable number of adjustable control parameters. With this increasing number of degrees of freedom (DoFs) for engines and the consequent considerable calibration effort required to optimize engine performance, traditional manual engine calibration or optimization methods are reaching their limits. An automated and efficient engine optimization approach is desired. In this paper, interdisciplinary research on a multiobjective evolutionary algorithm (MOEA)-based global optimization approach is developed for a homogeneous charge compression ignition (HCCI) engine. The performance of the HCCI engine optimizer is demonstrated by the cosimulation between an HCCI engine Simulink model and a Strength Pareto Evolutionary Algorithm 2 (SPEA2)-based multiobjective optimizer Java code. The HCCI engine model is developed by Simulink and validated with different engine speeds (1500-2250 r/min) and indicated mean effective pressures (IMEPs) (3-4.5 bar). The model can simulate the HCCI engine's indicated specific fuel consumption (ISFC) and indicated specific hydrocarbon (ISHC) emissions with good accuracy. The introduced MOEA optimization is an approach to efficiently optimize the engine ISFC and ISHC simultaneously by adjusting the settings of the engine's actuators automatically through the SPEA2. In this paper, the settings of the HCCI engine's actuators are intake valve opening (IVO) timing, exhaust valve closing (EVC) timing, and relative air-to-fuel ratio λ. The cosimulation study and experimental validation results show that the MOEA engine optimizer can find the optimal HCCI engine actuators' settings with satisfactory accuracy and a much lower time consumption than usual.