Mobile carrier ionophores for Fe(II)

S P Young; B D Gomperts

doi:10.1016/0005-2736(77)90164-X

Mobile carrier ionophores for Fe(II)

S P Young, B D Gomperts

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.

Original language	English
Pages (from-to)	281-91
Number of pages	11
Journal	Biochimica et Biophysica Acta (BBA) - Biomembranes
Volume	469
Issue number	3
DOIs	https://doi.org/10.1016/0005-2736(77)90164-X
Publication status	Published - 19 Sept 1977

Keywords

Humans
Lasalocid
Erythrocytes
Calcimycin
Cations, Divalent
Erythrocyte Membrane
Liposomes
Iron
Ionophores
Ferritins

Access to Document

10.1016/0005-2736(77)90164-XLicence: None: All rights reserved

Cite this

@article{02fb5eafae4d44a9bf89f6f691268ff8,

title = "Mobile carrier ionophores for Fe(II)",

abstract = "A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.",

keywords = "Humans, Lasalocid, Erythrocytes, Calcimycin, Cations, Divalent, Erythrocyte Membrane, Liposomes, Iron, Ionophores, Ferritins",

author = "Young, {S P} and Gomperts, {B D}",

year = "1977",

month = sep,

day = "19",

doi = "10.1016/0005-2736(77)90164-X",

language = "English",

volume = "469",

pages = "281--91",

journal = "Biochimica et Biophysica Acta (BBA) - Biomembranes",

issn = "0005-2736",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Mobile carrier ionophores for Fe(II)

AU - Young, S P

AU - Gomperts, B D

PY - 1977/9/19

Y1 - 1977/9/19

N2 - A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.

AB - A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.

KW - Humans

KW - Lasalocid

KW - Erythrocytes

KW - Calcimycin

KW - Cations, Divalent

KW - Erythrocyte Membrane

KW - Liposomes

KW - Iron

KW - Ionophores

KW - Ferritins

U2 - 10.1016/0005-2736(77)90164-X

DO - 10.1016/0005-2736(77)90164-X

M3 - Article

C2 - 332229

SN - 0005-2736

VL - 469

SP - 281

EP - 291

JO - Biochimica et Biophysica Acta (BBA) - Biomembranes

JF - Biochimica et Biophysica Acta (BBA) - Biomembranes

IS - 3

ER -

Mobile carrier ionophores for Fe(II)

Abstract

Keywords

Access to Document

Fingerprint

Cite this