Mobile carrier ionophores for Fe(II)

S P Young, B D Gomperts

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

A23187 and certain other carboxylate ionophores are capable of transferring Fe(II) but not Fe(III) across phospholipid bilayers (liposomes) and red cell membranes. A23187 is able to transfer Fe(II) from ferritin loaded liposomes when allied with a suitable redox couple and sink. The affinity of A23187 for Fe(II) is approximately five orders of magnitude greater than for Ca2+, as judged by two phase extraction techniques.
Original languageEnglish
Pages (from-to)281-91
Number of pages11
JournalBiochimica et Biophysica Acta (BBA) - Biomembranes
Volume469
Issue number3
DOIs
Publication statusPublished - 19 Sep 1977

Keywords

  • Humans
  • Lasalocid
  • Erythrocytes
  • Calcimycin
  • Cations, Divalent
  • Erythrocyte Membrane
  • Liposomes
  • Iron
  • Ionophores
  • Ferritins

Fingerprint

Dive into the research topics of 'Mobile carrier ionophores for Fe(II)'. Together they form a unique fingerprint.

Cite this